Echium oil reduces atherosclerosis in apoB100-only LDLrKO mice
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چکیده
منابع مشابه
Echium Oil Reduces Plasma Triglycerides by Increasing Intravascular Lipolysis in apoB100-Only Low Density Lipoprotein (LDL) Receptor Knockout Mice
Echium oil (EO), which is enriched in SDA (18:4 n-3), reduces plasma triglyceride (TG) concentrations in humans and mice. We compared mechanisms by which EO and fish oil (FO) reduce plasma TG concentrations in mildly hypertriglyceridemic male apoB100-only LDLrKO mice. Mice were fed one of three atherogenic diets containing 0.2% cholesterol and palm oil (PO; 20%), EO (10% EO + 10% PO), or FO (10...
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OBJECTIVES The enzyme acyl-coenzymeA (CoA):cholesterol O-acyltransferase 2 (ACAT2) in the liver synthesizes cholesteryl esters (CE) from cholesterol and fatty acyl-CoA, which get incorporated into apoB-containing lipoproteins that are secreted into the bloodstream. Dietary fatty acid composition influences the amount and fatty acid composition of CE within apoB-containing lipoproteins. We hypot...
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Objectives—The enzyme acyl-coenzymeA (CoA):cholesterol O-acyltransferase 2 (ACAT2) in the liver synthesizes cholesteryl esters (CE) from cholesterol and fatty acyl-CoA, which get incorporated into apoB-containing lipoproteins that are secreted into the bloodstream. Dietary fatty acid composition influences the amount and fatty acid composition of CE within apoB-containing lipoproteins. We hypot...
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Macrophage inflammation marks all stages of atherogenesis, and AMPK is a regulator of macrophage inflammation. We therefore generated myeloid α1AMPK knockout (MAKO) mice on the LDL receptor knockout (LDLRKO) background to investigate whether myeloid deletion of α1AMPK exacerbates atherosclerosis. When fed an atherogenic diet, MAKO/LDLRKO mice displayed exacerbated atherosclerosis compared with ...
متن کاملPeanut oil reduces diet-induced atherosclerosis in cynomolgus monkeys.
The atherogenicity of dietary peanut oil (PO) was examined in cynomolgus monkeys fed semipurified diets for 15 months. Four groups of six monkeys were fed diets containing 0.22 mg/kcal (0.1%) cholesterol and 0%, 5%, 10%, or 20% PO. An additional group was fed 2.0% cholesterol and 20% PO to serve as a literature control. Increasing the concentration of PO in the diet was associated with signific...
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ژورنال
عنوان ژورنال: Atherosclerosis
سال: 2012
ISSN: 0021-9150
DOI: 10.1016/j.atherosclerosis.2011.10.025